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Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 784-798 doi: 10.1007/s11684-021-0911-0

Abstract: More than 85% of patients with uveal melanoma (UM) carry a GNAQ or GNA11GNAQ/11 relies on palmitoylation for membrane association and signal transduction.cells without GNAQ/11 mutations./11-mutant UM cells and showed a notable synergistic effect when applied in combination with thetherapeutic target for GNAQ/11-driven UM.

Keywords： uveal melanoma     mutant GNAQ/11     palmitoylation     BCL2     combination target therapy    

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Effects of the SAPO-11 synthetic process on dehydration of ethanol to ethylene

Lina WU, Xiaoxing SHI, Qun CUI, Haiyan WANG, He HUANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1,   Pages 60-66 doi: 10.1007/s11705-010-0540-7

Abstract: The effects of the synthetic condition of SAPO-11 molecular sieves on ethanol dehydration to ethyleneProduct-compositions, ethanol conversion, and selectivity to ethylene of synthesized and commercial SAPO-11From the patterns of NH -TPD, the amount of acid synthesized by SAPO-11 molecular sieves is less thanthat by commercial SAPO-11 molecular sieves, and has a stronger weak acid.by 20°C compared to commercial SAPO-11.

Keywords： SAPO-11 molecular sieves     synthesis     ethanol     ethylene     dehydration    

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Mechanistic insights into the selective photocatalytic degradation of dyes over TiO/ZSM-11

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 8, doi: 10.1007/s11783-023-1701-5

Abstract:

● TiO2/ZSM-11 was prepared by a facile solid state dispersion

Keywords： Selective dye degradation     Photocatalysis     TiO2     ZSM-11     Chemisorption    

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Organic Contaminants in Chinese Surface Water: Identification of Priority Pollutants” [Engineering 11 Corrigendum

Mengmeng Zhong, Tielong Wang, Wenxing Zhao, Jun Huang, Bin Wang, Lee Blaney, Qingwei Bu, Gang Yu

Engineering 2023, Volume 31, Issue 12,   Pages 139-140 doi: 10.1016/j.eng.2022.09.001

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Dynamic mechanism for the decline of China’s energy intensity during the 11th FYP (Five-Year Plan)

Minghui LI

Frontiers in Energy 2011, Volume 5, Issue 3,   Pages 237-249 doi: 10.1007/s11708-010-0130-x

Abstract: towards its goal of achieving approximately a 20% reduction in energy intensity during the period of the 11thproperties of the mechanism for the decrease in China’s energy intensity since the beginning of the 11thbefore 2000, technical energy savings have been the main driver of momentum since the beginning of the 11th

Keywords： energy intensity     structural energy savings     technical energy savings    

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Grouting construction technology of high pressure and rich water fault F11 in Qiyueshan Tunnel

Zhuo Yue,Sun Guoqing

Strategic Study of CAE 2009, Volume 11, Issue 12,   Pages 82-86

Abstract: Fractured fault F11, which has high water pressure, large volume of water gushing and complicated geologicalTaking the technologies of grouting, water control and rock collapse prevention adopted for fault F11examination method for water control and rock collapse prevention in high pressure and rich water fault F11

Keywords： Qiyueshan Tunnel     fractured fault     technical challenges     new construction scheme     new construction technology     effect examination method    

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The Security Analysis for Enhanced Data Encryption Schemes in IEEE802.11/11b WLAN

Song Yubo,Hu Aiqun,Cai Tianyou

Strategic Study of CAE 2004, Volume 6, Issue 10,   Pages 32-38

Abstract:

As an expansion of LAN, the WLAN reduce the cost of building a network infrastructure, to enjoy the mobile, high-quality, multimedia services. The 802.11 standard for wireless networks includes a Wired Equivalent Privacy (WEP) protocol, which is used to protect link-layer communications from eavesdropping and other attacks. Several serious security flaws in this protocol have been discovered and some solutions have been proposed to enhance WEP security. However, it is doubtful whether they can provide enough security as these solutions lack precisely security analysis. In this paper, concrete security analyses of various enhancing mechanisms are given. Results show that these mechanisms indeed increase security and bring significant, provable security gains in WLAN environment. The authors quantify the security as a function of the security of the primitives used, thereby enabling a user to decide how to construct an enhanced mechanism for desired demands.

Keywords： WLAN     encryption     WEP     rekey    

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gene expression during melanoblasts migration in normal pigmented White Leghorn and hyperpigmented mutant

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 299-306 doi: 10.15302/J-FASE-2014040

Abstract: Melanoblasts originating from neural crest cells can migrate through the mesenchyme of the developed embryo and give rise to melanocytes. Unlike the melanocytes that are confined to the integument in other vertebrates, melanocytes in Silky Fowl can reach the ventral regions of the embryos owing to differences in gene expression in the process of melanoblasts migration. In this study, we used microarray profiling to identify differences in gene expression between White Leghorn and Silky Fowl. Differential expression of 2517 microarray probes ( <0.01, Fold Change>2) was observed in Silky Fowl compared to White Leghorn. After filtration by cluster analysis, functional annotation and pathway analysis, eight differentially expressed genes were identified to be closely related to the development of melanocytes. Moreover, differences in expression of immune genes were also detected between Silky Fowl and White Leghorn. The differentially expressed genes associated with melanocyte development were verified by q-PCR, and results were highly consistent with the microarray data. The genes with significantly altered expression involved in melanoblast migration and development suggested that different microenvironments resulted in the abnormal melanoblast migration in Silky Fowl, although there were no big differences in melanoblast development between these two breeds. The candidate genes discovered in this study are beneficial to understand the molecular mechanism of hyperpigmentation in Silky Fowl.

Keywords： Silky Fowl     White Leghorn     melanoblast migration     gene expression    

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Neutron Diffraction Investigation of the DyFe11Ti Magnetic Structure and Its Spin Reorientations Article

Olivier Isnard, Eder J. Kinast

Engineering 2020, Volume 6, Issue 2,   Pages 153-157 doi: 10.1016/j.eng.2019.11.009

Abstract:

In this article, we report on the magnetic structure of DyFe11Ti and its thermal evolution

Keywords： Neutron diffraction     Magnetic phase diagram     Crystal structure    

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and clinical application of anti-HBs monoclonal antibody that binds both wild-type and immune escape mutant

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 277-283 doi: 10.1007/s11684-009-0047-0

Abstract: antibody, we developed a sandwich ELISA (defined G6m ELISA) for detecting both wild-type and immune escape mutant

Keywords： hepatitis B virus     gene variation     hepatitis B surface antigen     immune escape     enzyme-linked immunosorbent assay    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract:

Genetic mutations are considered to drive the development of acute myeloid leukemia (AML). With the rapid progress in sequencing technologies, many newly reported genes that are recurrently mutated in AML have been found to govern the initiation and relapse of AML. These findings suggest the need to distinguish the driver mutations, especially the most primitive single mutation, from the subsequent passenger mutations. Recent research on DNA methyltransferase 3A (DNMT3A) mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells (pre-LSCs) in AML patients. Although DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia, the function of this driver mutation appear to persist from AML initiation up to relapse. Therefore, identifying and targeting preleukemic mutations, such as DNMT3A mutations, in AML is a promising strategy for treatment and reduction of relapse risk.

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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PRODUCTION OF NEW WAP-8294A CYCLODEPSIPEPTIDES BY THE BIOLOGICAL CONTROL AGENT LYSOBACTER ENZYMOGENES OH11

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 120-132 doi: 10.15302/J-FASE-2021410

Abstract: new analogs of WAP-8294A compounds by the biocontrol agent Lysobacter enzymogenes OH11

Keywords： biocontrol / biosynthesis / Lysobacter / natural products / WAP-8294A    

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Co-conversion of methanol and

Shumei Wei, Yarong Xu, Zhaoyang Jin, Xuedong Zhu

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 783-792 doi: 10.1007/s11705-019-1868-2

Abstract: In this study, intergrown ZSM-5/ZSM-11 crystals were synthesized and their resulting catalytic performancewas investigated and compared to those of the isolated ZSM-5 and ZSM-11 zeolites.The physicochemical properties of ZSM-5/ZSM-11 intergrown zeolite were analyzed using X-ray diffractionCompared to the ZSM-5 and ZSM-11 zeolites, the ZSM-5/ZSM-11 zeolite exhibited the largest specific surfaceThe evaluation results showed that ZSM-5/ZSM-11 catalyst exhibited better catalytic reactivity than the

Keywords： ZSM-5/ZSM-11     methanol     n-hexane     cofeeding     aromatics    

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Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 275-279 doi: 10.1007/s11684-012-0216-4

Abstract:

PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses toAgainst original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was firstHowever, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesisThis review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in

Keywords： PTPN11/Shp2     leukemia     hepatocellular carcinoma     mutation    

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High production of butyric acid by

Chao Ma,Jianfa Ou,Matthew Miller,Sarah McFann,Xiaoguang (Margaret) Liu

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 369-375 doi: 10.1007/s11705-015-1525-3

Abstract: to improve the production of butyric acid by process optimization using the metabolically engineered mutant

Keywords： Clostridium tyrobutyricum     butyric acid production     fermentation     mutant     pH     flux balance analysis    

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Title Author Date Type Operation

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal

Journal Article

Effects of the SAPO-11 synthetic process on dehydration of ethanol to ethylene

Lina WU, Xiaoxing SHI, Qun CUI, Haiyan WANG, He HUANG

Journal Article

Mechanistic insights into the selective photocatalytic degradation of dyes over TiO/ZSM-11

Journal Article

Organic Contaminants in Chinese Surface Water: Identification of Priority Pollutants” [Engineering 11

Mengmeng Zhong, Tielong Wang, Wenxing Zhao, Jun Huang, Bin Wang, Lee Blaney, Qingwei Bu, Gang Yu

Journal Article

Dynamic mechanism for the decline of China’s energy intensity during the 11th FYP (Five-Year Plan)

Minghui LI

Journal Article

Grouting construction technology of high pressure and rich water fault F11 in Qiyueshan Tunnel

Zhuo Yue,Sun Guoqing

Journal Article

The Security Analysis for Enhanced Data Encryption Schemes in IEEE802.11/11b WLAN

Song Yubo,Hu Aiqun,Cai Tianyou

Journal Article

gene expression during melanoblasts migration in normal pigmented White Leghorn and hyperpigmented mutant

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

Journal Article

Neutron Diffraction Investigation of the DyFe11Ti Magnetic Structure and Its Spin Reorientations

Olivier Isnard, Eder J. Kinast

Journal Article

and clinical application of anti-HBs monoclonal antibody that binds both wild-type and immune escape mutant

Fanghe LI BM , Chunyan ZHANG MS , Jinghua LIU MS , Xiaoyan ZHANG MS , Bing YAN , Bo ZHANG MS , Yongguo HUANG MS , Jingsong GONG BM , Yan CHEN BM ,

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

PRODUCTION OF NEW WAP-8294A CYCLODEPSIPEPTIDES BY THE BIOLOGICAL CONTROL AGENT LYSOBACTER ENZYMOGENES OH11

Journal Article

Co-conversion of methanol and

Shumei Wei, Yarong Xu, Zhaoyang Jin, Xuedong Zhu

Journal Article

Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Journal Article

High production of butyric acid by

Chao Ma,Jianfa Ou,Matthew Miller,Sarah McFann,Xiaoguang (Margaret) Liu

Journal Article